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Health benefits/risks from testosterone replacement therapy

Several studies have investigated the potential effects of testosterone therapy on blood glucose control in men with low testosterone levels (Low T). Here are a few examples:

  1. A 2016 meta-analysis of 23 randomized controlled trials found that testosterone therapy was associated with a significant reduction in fasting blood glucose levels in men with Low T.

  2. A 2013 study published in the Journal of Diabetes Science and Technology found that testosterone therapy improved insulin sensitivity and glucose metabolism in men with type 2 diabetes and Low T.

  3. A 2011 study published in the European Journal of Endocrinology found that testosterone therapy improved insulin sensitivity and glucose metabolism in men with Low T and type 2 diabetes.

  4. A 2010 study published in the Journal of Clinical Endocrinology and Metabolism found that testosterone therapy improved insulin sensitivity and glucose metabolism in men with Low T and obesity.


The potential cardiovascular benefits of testosterone replacement therapy (TRT) in men have been a topic of debate and investigation for many years. While some studies have suggested that TRT may have cardiovascular benefits, others have raised concerns about potential risks.

Here are a few examples of studies that have investigated the potential cardiovascular benefits of TRT in men:

  1. A 2016 meta-analysis of 39 randomized controlled trials found that TRT was associated with a significant reduction in all-cause mortality and cardiovascular events (such as heart attack and stroke) in men with low testosterone levels.

  2. A 2015 study published in the Journal of the American Heart Association found that TRT was associated with a reduced risk of cardiovascular events in men with low testosterone levels and no history of heart disease.

  3. A 2013 study published in the European Heart Journal found that TRT was associated with improvements in several markers of cardiovascular health, including arterial stiffness and endothelial function, in men with coronary artery disease and low testosterone levels.


Here are a few examples of studies that have investigated potential negative cardiovascular effects of TRT in men:

  1. A 2015 study published in the New England Journal of Medicine found that TRT was associated with an increased risk of cardiovascular events (such as heart attack, stroke, and death) in men with low testosterone levels and existing cardiovascular disease. The study was stopped early due to safety concerns.

  2. A 2014 study published in the journal PLoS One found that TRT was associated with an increased risk of heart attack in men over the age of 65 and in younger men with a history of heart disease.

  3. A 2013 study published in the Journal of the American Medical Association found that TRT was associated with an increased risk of stroke, heart attack, and death in older men with low testosterone levels and existing cardiovascular disease.


There is some evidence that low testosterone levels may be associated with an increased risk of cardiovascular disease (CVD) in men. However, the relationship between testosterone replacement therapy (TRT) and cardiovascular disease is complex and still not fully understood.



While some studies have suggested that TRT may have cardiovascular benefits, others have raised concerns about potential risks. For example, some studies have suggested that TRT may increase the risk of cardiovascular events such as heart attack and stroke in older men or in men with existing cardiovascular disease.


It's worth noting that the available evidence on TRT and cardiovascular disease is somewhat mixed, and more research is needed to fully understand the potential risks and benefits of TRT in relation to cardiovascular health. In general, the decision to use TRT should be made on a case-by-case basis, taking into account individual health status, medical history, and potential risks and benefits. TRT should only be administered under the supervision of a qualified and licensed healthcare provider.




If you have concerns about your cardiovascular health and whether TRT may be appropriate for you, it's important to discuss these issues with your healthcare provider. They can help you understand the potential risks and benefits of TRT in your individual case and help you make an informed decision about whether TRT is right for you.





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